Georgina Meneses-Lorente Selected Research

entrectinib

1/2023	Entrectinib dose confirmation in pediatric oncology patients: pharmacokinetic considerations.
10/2022	Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG).
1/2022	Efficacy and safety exposure-response analyses of entrectinib in patients with advanced or metastatic solid tumors.
1/2022	In vitro and clinical investigations to determine the drug-drug interaction potential of entrectinib, a small molecule inhibitor of neurotrophic tyrosine receptor kinase (NTRK).
12/2021	Population pharmacokinetic analysis of entrectinib in pediatric and adult patients with advanced/metastatic solid tumors: support of new drug application submission.
1/2021	Characterization of the pharmacokinetics of entrectinib and its active M5 metabolite in healthy volunteers and patients with solid tumors.
1/2020	Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib.

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Georgina Meneses-Lorente Research Topics

Disease

16	Neoplasms (Cancer) 01/2023 - 04/2015
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2022 - 09/2017
3	Diarrhea 10/2018 - 01/2018
3	Breast Neoplasms (Breast Cancer) 10/2018 - 01/2018
2	Rare Diseases (Rare Disease) 01/2022 - 08/2015
2	Fatigue 01/2022 - 10/2020
1	Central Nervous System Neoplasms 10/2022
1	Exanthema (Rash) 01/2022
1	Edema (Dropsy) 10/2020
1	Giant Cell Tumor of Tendon Sheath 01/2020
1	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 01/2019
1	Carcinoma (Carcinomatosis) 09/2017
1	Pigmented Villonodular Synovitis 08/2015
1	Asthenia 08/2015
1	Pruritus (Itching) 08/2015
1	Genetic Translocation (Chromosomal Translocation) 08/2015
1	Head and Neck Neoplasms (Head and Neck Cancer) 04/2015
1	Type 2 Diabetes Mellitus (MODY) 07/2013
1	Atherosclerosis 07/2013
1	Glioma (Gliomas) 06/2013
1	Exfoliative Dermatitis (Erythroderma) 06/2013
1	Fatty Liver 05/2004

Drug/Important Bio-Agent (IBA)

7	entrectinibIBA 01/2023 - 01/2020
7	Monoclonal AntibodiesIBA 01/2022 - 02/2016
7	lumretuzumabIBA 10/2018 - 04/2015
5	emactuzumabIBA 01/2022 - 08/2015
4	Proteins (Proteins, Gene)FDA Link 09/2017 - 05/2004
3	pertuzumabIBA 10/2018 - 01/2018
3	Paclitaxel (Taxol)FDA LinkGeneric 10/2018 - 01/2018
2	Tyrosine Kinase InhibitorsIBA 10/2022 - 01/2020
2	Anaplastic Lymphoma KinaseIBA 01/2022 - 01/2021
2	Phosphotransferases (Kinase)IBA 01/2022 - 01/2021
2	tyrosine receptor (receptor, tyrosine)IBA 01/2022 - 01/2021
2	Macrophage Colony-Stimulating FactorIBA 10/2020 - 08/2015
2	ErbB Receptors (EGF Receptor)IBA 10/2018 - 10/2017
2	Loperamide (Imodium)FDA LinkGeneric 10/2018 - 01/2018
2	Biomarkers (Surrogate Marker)IBA 09/2017 - 05/2004
1	TropomyosinIBA 01/2023
1	atezolizumabIBA 01/2022
1	LigandsIBA 01/2022
1	Immune Checkpoint InhibitorsIBA 01/2022
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021
1	selicrelumabIBA 10/2020
1	CreatinineIBA 10/2020
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2020
1	obinutuzumabIBA 01/2019
1	Bendamustine Hydrochloride FDA Link 01/2019
1	GalliumIBA 01/2019
1	AntibodiesIBA 01/2018
1	Chloride Channels (Chloride Channel)IBA 01/2018
1	AntidiarrhealsIBA 01/2018
1	Neuregulin-1 (Neuregulin 1)IBA 09/2017
1	Cetuximab (Erbitux)FDA Link 09/2017
1	Messenger RNA (mRNA)IBA 09/2017
1	histidine-rich proteinsIBA 09/2017
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 09/2017
1	HDL CholesterolIBA 07/2013
1	Cholesterol Ester Transfer ProteinsIBA 07/2013
1	Capecitabine (Xeloda)FDA Link 06/2013
1	Alanine Transaminase (SGPT)IBA 06/2013
1	TabletsIBA 06/2013
1	Serum AlbuminIBA 05/2004
1	Aryldialkylphosphatase (Paraoxonase)IBA 05/2004
1	Blood Proteins (Serum Proteins)IBA 05/2004
1	Glucose (Dextrose)FDA LinkGeneric 05/2004
1	PeroxiredoxinsIBA 05/2004

Therapy/Procedure

3	Therapeutics 01/2018 - 07/2013
2	Drug Therapy (Chemotherapy) 01/2019 - 01/2018
1	Duration of Therapy 10/2022
1	Aftercare (After-Treatment) 01/2020
1	Drug Tapering 01/2018
1	Radiotherapy 06/2013